What is a significant adverse effect associated with Amiodarone (Cordarone)?

Amiodarone, a class III antiarrhythmic medication, is commonly used for the treatment of various types of cardiac arrhythmias. One significant adverse effect associated with amiodarone is hypotension, particularly when it is administered intravenously or when given alongside other medications that may lower blood pressure.

Hypotension can occur due to several mechanisms. Amiodarone has vasodilating properties, which can lead to a decrease in systemic vascular resistance and consequently lower blood pressure. This effect is particularly critical to monitor in acute settings, where rapid administration during arrhythmias can lead to a sudden drop in blood pressure, potentially compromising perfusion.

While other options like diarrhea, skin rash, and weight gain can occur with amiodarone use, they are typically less acute or less significant in the context of life-threatening situations that paramedics often encounter. In clinical practice, maintaining adequate blood pressure is crucial for ensuring tissue perfusion and managing patients' hemodynamic stability, making hypotension a particularly noteworthy adverse effect of amiodarone.